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Tribune Special
Nobel
Prize in science |
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Profile On Record
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Nobel Prize in science
Nobel
Prizes are rightly regarded as the highest recognition that one can get in areas like physics, chemistry, physiology and medicine. It is also true that for every Nobel Prize winner, there are a number of equally (sometimes even more) deserving who did not win the prize. For example, how many would have heard of Waksman who received a Nobel Prize for the discovery of streptomycin, which was hardly exciting after the Nobel Prize to Fleming for his discovery of penicillin? On the other hand, J.D. Bernal who co-discovered operational research and is considered to be one of the most brilliant and productive physicists of the last century, and J.B.S. Haldane, never received the prize. Then there are those who may not have been known widely or publicly because of their low-profile lifestyle but who surely deserved a Nobel Prize. Amongst those whom I have known well, I believe Alex Rich (who discovered polyribosomes that act as a platform for synthesis of proteins in all living cells, and the three-dimensional structure of t-RNA which acts as the pawn broker in the transfer of information from DNA to protein in all living material), Paul Zamecnik (the discoverer of t-RNA which is one of the most important and universal constituents of all cells), the late Seymour Benzer (who, amongst other major discoveries, also discovered the first behavioural mutants in living systems and worked out methods to separate and study them), the late G.N. Ramachandran (the best known Indian biologist) and Premkumar Reddy (who discovered the first mutation in a normal cell that leads to cancer and is one of the hundred most cited scientists in the world), have been worthy of a Nobel Prize. There are also cases where a Nobel Prize should have been awarded but was not because of (almost certainly) a sex bias. Two examples are of Lisa Meitner, the physicist who made vital contributions to nuclear physics and the subsequent nuclear revolution, along with scientists like Niels Bohr (who did receive a Nobel Prize), and Rosalind Franklin whom I knew and who, it is widely believed, should have shared the Nobel Prize for the discovery of structure of DNA, which was given to Francis Crick, Jim Watson and Maurice Wilkins. Between Wilkins and Franklin, the appropriate choice should have been Franklin but Wilkins was the head of the laboratory and Rosalind a very shy and modest (and a very pretty) woman! At least two Nobel Prizes have been given for discoveries that were subsequently proven to be wrong. Heinrich Wieland was given a Nobel Prize in Chemistry in 1927 for the discovery of the structure of cholic acid, which structure was proven to be wrong within a year of the award. And in 1959, two of my friends (now no more), Severo Ochoa and Arthur Kornberg, received a Nobel Prize for the discovery of enzymes (biological catalysts) that carry out the synthesis of RNA and DNA (chemicals responsible for heredity in living systems) which turned out to be the wrong enzymes. There are, however, cases where there are reasons for far more serious complaint. I will mention two such cases. The first case is of Sam Weiss who discovered the enzyme (enzymes are biophysical catalysts and are mostly proteins), RNA polymerase, that makes RNA which has a replica of the genetic information contained in the DNA of all living cells. RNA (ribonucleic acid) is an essential constituent of all cells excepting certain viruses, and performs many important functions such as in protein synthesis; it also acts as a genetic material of certain viruses. If one were to choose the most important enzyme out of the thousands known, RNA polymerase will probably be voted at the top. Ochoa received the Nobel Prize for discovering the wrong enzyme for making RNA. Sam Weiss’ discovery of the right enzyme was far more important and central to modern biology, but he was ignored for he was self-effacing. But perhaps, the most glaring mistake the Nobel Foundation has ever committed is in regard to the award of the Nobel Prize for Physiology/Medicine announced on October 6, 2008 to Luc Montagnier, Francoise Barre-Sinoussi, and Harald zur Hausen. While I welcome this recognition of the work of Luc Montagnier and Francoise Barre-Sinoussi on the AIDS-causing virus, HIV, I am shocked that Robert Gallo, the co-discoverer of the virus, has been excluded from the award. I have known both Bob Gallo and Luc Montagnier well for nearly four decades, and say this against the background of intimate knowledge and understanding of their scientific work; with Luc Montagnier, I have a joint publication (Journal of Membrane Biology: 1926, 26, 1-17). Bob Gallo was responsible for creating the first awareness — both in the scientific community and in the public — of the virus. His work on HIV and AIDS has both depth and breadth that has not been excelled by any other scientist. He is also accredited with other major discoveries such as of the human leukemia-causing viruses and interleukin-2. He is one of the hundred most highly cited scientists in the world and is a winner of virtually every major scientific award, including the Lasker Award which is widely considered as a prelude to the Nobel Prize. Bob Gallo also has had the courage to make mistakes and then later recognise that he made a mistake. He has been extremely vocal and has known the joy of living. I found it difficult to make Luc Montagnier smile, while Bob Gallo’s laughter could be heard across the laboratory’s corridor. Both Luc and Bob enjoy excellent wine. But then, there is a lot more (such as company of pretty women!) for a man to enjoy life. In this respect — as in respect of scientific accomplishments — Bob has had a clear edge over Luc. Was all this a fault? This is not to imply that a Nobel Prize should not have been given to Harald zur Hausen. Surely, it could have been given in the following year. Alternatively, Bob Gallo, Luc Montagnier and Francoise Barre-Sinoussi could have shared a Nobel Prize next year. The above exclusion of Bob Gallo would probably go down in history as the worst mistake ever made in the history of Nobel Prizes.
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Profile Bharat
Ratna, the country’s highest civilian award, was caught up in political controversy this year as BJP leader L.K. Advani, sought it for Atal Bihari Vajpayee while the Congress favoured veteran Marxist leader Jyoti Basu and Mayawati pitched for BSP founder Kanshi Ram. The selectors rightly decided to bypass the three stalwarts and zeroed on Bhimsen Joshi, a non-political personality. The Doyen of Indian classical music, he is known as music’s renaissance man. His rendition of Mile Sur Mera Tumhara Too Sur Bane Hamara, along with other doyens of music, virtually became an unofficial national anthem way back in 1988. The top honour for the 86-year-old Joshi caps a distinguished career, spanning over seven decades since his first performance at the age of 19. A descendent of Kirana Gharana, Joshi is renowned particularly for the Khayal form of singing, and for his Bhajans. His debut album, containing a few devotional songs in Kannada and Hindi, was released when he was barely 20. There is a magic in Bhimsen’s voice which keeps the listeners spellbound. His bhajans, More Ghar Aao Pyare, Tan Man Dhan Saab Bhent Karungi and Piya Too Manat Nahin drown the listeners in melody. Joshi is indeed a musical marvel. Bhimsen was born into a Brahmin family of Gadag in Karnataka. His childhood was spent there. Even as a child he was crazy about music, to the disappointment of his father who desired that Bhimsen should get sound education and qualify as a doctor or an engineer. But Bhimsen, neglecting his studies, pursued music instead. At last he could not control any more his yearning to learn music, and one day he ran away from home. He had heard that Gwalior, Lucknow and Rampur in the North were the best places to learn classical music. Therefore, his first destination was Gwalior. A few years of his youth were thus spent in the company of well known musicians at Gwalior, Lucknow and Rampur, serving them and learning as much as he could from them. His father, having been convinced of Bhimsen’s fervent desire for knowledge of music, abandoned his policy of opposition, brought his son back and made arrangements for him to learn under the guidance of Sawai Gandharva of Kundol. This opportunity opened the vaults of rich and rare musical treasures to Bhimsen. His natural tuneful voice received further polish from his guru. Like a diamond which sparkles all the brighter after it is expertly cut, Bhimsen’s voice began to shine with a new lustre and brilliance which dazzled and cast a spell on the entire country. With his experience, Bhimsen began to understand the psychology of his audience. He would gauge the intellectual level of his listeners within minutes of the start of a concert and cater to their taste, drawing applause. He would keep the listeners spellbound, fully under control. For the audience, it was a visible treat which carried them to celestial heights. Bhimsen’s name and fame rose like a meteor and he began receiving invitations from far off places. One night he would be in Kolkata, the next day in Delhi and the following evening in Mumbai. He had to switch over to air travels to keep up his appointments. The pilots of Indian Airlines and airport officials came across Joshi so often that he has come to be known as “Flying musician of India”. Every year Bhimsen observes the punyatithi (death anniversary) of his Guru Sawai Gandharva with a music festival in Pune. For three consecutive nights, about 10,000 people attend the programme from 8 p.m. to 7 a.m. The spectacle is one fit for gods as eminent classical prodigies vie with each other to enthrall the audience. Supreme confidence in his own abilities and unfailing commitment to music remain intact as Bhimsen touches 86 and races towards nineties. His fans wish him a long and healthy life. |
On Record
Despite
the economic crisis threatening to get into a deflationary spiral, India and China will continue to grow robustly in the long-term. However, if India has to take the lead as the Asian tiger, it has to take some convincing action on the fiscal management front, says Manoj Vohra, Research Director, Economist Intelligence Unit (EIU). In an interview to The Sunday Tribune, he dwells upon how things will change for India and neighboring China and says that fiscal and monetary measures taken by India to counter the crisis have been inadequate and rather belated. China, on the other hand, has been more fleet footed and is better positioned, he feels. Excerpts: A:
We have not seen the worst impact of the meltdown as yet; the real crisis will begin to unfold in 2009 with the contraction of economies in the US, Euro zone and Japan. In Asia, countries like Korea and Taiwan will also see a sharp slowdown and some economies in Eastern Europe look vulnerable. However, China and India will be relatively resilient to the crisis. Q: What is the EIU’s forecast of growth for India and China? A:
As per our forecast currently India will witness a real GDP growth of 6.3 per cent in 2008-09, and 6.1 per cent in the next year. We had predicted that the growth of 8-9 per cent in India was not sustainable and was a sure sign of overheating. India needs to match its rapidly growth demand with supply-side expansion, enhance productivity, further liberalise FDI norms and address infrastructural inadequacies. Q: How do you see the global economic crisis impacting India going forward? A:
The fallout from the global financial crisis has had an increasingly severe impact on India, causing the stock market and currency to slump and the banking sector to experience a sudden liquidity crisis. FDI is also expected to witness a negative impact. The economic slowdown was initially restricted to the industrial sector, but the most recent data show that it is spreading to the services. Moreover, the risks are on the downside, as India’s budget and external deficits put the government in a relatively weak position to implement supplementary fiscal measures if the global downturn proves to be more severe than we are forecasting. Whereas the RBI has responded vigorously, if somewhat belatedly, to the crisis by boosting liquidity and loosening monetary policy, the federal government is not in a strong position to respond with supplementary fiscal measures. Fiscal policy had already been loosened in the pre-election budget for fiscal year 2008-09, and any further stimulus will worsen the overshoot of the official budget deficit projections. By contrast, the RBI has had a complete reversal of policy, pumping liquidity into the banking system and cutting interest rates aggressively. Some believe that public sector banks are under pressure from the government to lower interest rates. This is unlikely to restore sustained confidence in the market in the foreseeable future. Q: Where do you see the inflationary pressure in coming days? Will it ease? A:
The Economist Intelligence Unit expects consumer price inflation to average 7.8 per cent in 2008-09 and 6.7 per cent in 2009-10. We expect inflation to fall to single digits by the end of this fiscal year. India will remain vulnerable to upward inflationary pressures over the next 12-18 months on three main counts: First, the rupee is not expected to regain all of its recent losses and could come under renewed downward pressure. Second, the implementation of substantial pay rises for 5m government workers in January 2009, significantly above the recommendations of the Sixth Pay Commission, will have significant knock-on effects on other public-sector pay rises. And third, the collapse of global oil prices since August will not cut inflation in India much as domestic fuel prices are heavily subsidised and were shielded from the oil price surge in late 2007 and the first half of 2008. Q: What kind of fiscal measures will help improve the overall economic situation? A:
We suggest, among others, rationalising taxes and duties to expand the tax base. The government needs to do some serious thinking on the fiscal management front. It should check wasteful public spending and undertake administrative reforms in an accelerated manner. |
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