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Mapping the brain is a very difficult task but the challenge has been taken up by an Indian neuroscientist, Partha Mitra, who moved to the US years ago. He was recently awarded the prestigious $300,000 grant under President Barack Obama’s initiative to map the human brain. The grant will help him develop an artificial intelligence system that can identify cell and neural structures in microscopic images of brain slices. Mitra is working on an integrative picture of brain function, incorporating theory and experimental work. He is also the founder of the Mouse Brain Architecture Project, an experimental effort to develop a brain-wide connectivity map of mouse brain. The human brain has an estimated trillion neurons and many neurons have dendrites (branched extension of nerve cell) with thousands of connections. Mapping the brain is tough. And if somehow the entire brain can be mapped, it would still be difficult to know how it works. It apparently uses parallel processing rather than linear processing like a computer. A professor at Cold Spring Harbor Laboratory, Mitra’s work involves developing an understanding of the behaviour of complex biological system by developing tools for analysis and building knowledge bases of neurobiological literature. His experimental work includes the study of memory formation. Mitra says: “Our goal is to obtain conceptual breakthrough into how brains work. Despite extensive research, we are still far from comprehensive understanding of how the nervous system gives rise to the behavioural complexities, cognition and affect. We do not yet know what precisely goes wrong in human brains in most major neuropsychiatric disorders, and therapeutic advances remain slow. Nervous systems are complex, with multiple scales or organisations ranging from single cells to the whole organism and social-environmental inactions. As a result, there remain large empirical gaps in our knowledge that can only be filled in experimentally. However, an equally important problem is that of integrating the information thus obtained.” His work has spanned the different scales of nervous system organisation. The laboratory has previously focused on analysing behavioural and electrophysiological measurement in a number of model organisms. Currently, the laboratory is focused on the Brain Architecture Project which aims at a whole-brain level of analysis of neural circuitry. The project aims at a whole-brain level of analysis of neural circuitry. The Mouse Brain Architecture Project is systematically mapping the whole brain of the mouse, and simultaneously addressing the computational and theoretical questions that arise. An ongoing theoretical programme also addresses the fundamental engineering and design principles of the nervous system. According to reports published in the New York Times, the breakthrough in mapping the brain technology will provide answers to Alzheimer disease and Schizophrenia and lead us out of the “impenetrable jungles of the brain” that neuroscientists have wandered over the past century. |
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