|
|
|
| SCIENCE & TECHNOLOGY |
|
|
|
Gene therapy
for the unborn Trends
THIS UNIVERSE |
|
|
Gene therapy
for the unborn Scientists are on the verge of ridding inherited diseases from future generations with a new technique for swapping genes between unfertilised The technique has been successfully tested on laboratory monkeys and researchers believe it is now safe enough to apply for clinical trials on the many thousands of women at risk of giving birth to babies with some of the most debilitating inherited disorders. This form of gene therapy, known as germline gene therapy, alters the DNA of sperm or eggs and is banned in Britain because of fears over its safety as well as the prospect of its leading to the creation of “designer babies”. However, a clause in the new Human Fertilisation and Embryology Act, which comes into force on 1 October, could permit a type of germline gene therapy involving mitochondrial DNA n which exists outside the chromosomes n without the need for changes to primary legislation and a Parliamentary vote. Mitochondria, the tiny “power houses” of cells and their DNA, which lies outside the nucleus, is inherited solely down the maternal line. It is estimated that 1 in every 200 babies are born with mitochondrial mutations, some of which can lead to serious, life-long illnesses, such as diseases of muscles and nerves, as well as diabetes and cancer. The study on monkeys involved “renewing” the mitochondria of their eggs by the wholesale transfer of the chromosomes of one of their eggs into the egg of a donor female that had its own chromosomes removed so that only her mitochondrial DNA was left. The aim was to test the feasibility of taking eggs from women with one of the 150 known mitochondrial DNA disorders and using them to create healthy eggs by transferring their chromosomes into donor eggs with no chromosomes of their own. The resulting egg would have DNA from two females and, when fertilised with a sperm, would result in an embryo which has three genetic parents. In the latest study, four healthy macaque monkeys have been born using the technique. The scientists involved said yesterday there is no evidence that the procedure is unsafe and that they were planning to apply for ethical approval to conduct clinical trials in humans within a few years. “In theory, this research has demonstrated it is possible to use this therapy in mothers carrying mitochondrial DNA diseases so that we can prevent those diseases from being passed on to their offspring,” said Shoukhrat Mitalipov of Oregon Health and Science University in Beaverton, Oregon. “We believe with proper governmental approvals, our work can rapidly be translated into clinical trials for humans, and approved therapies,” said Dr Mitalipov, whose study with colleague Masahito Tachibana is published in the journal Nature. Conventional gene therapy has been tried in humans for 20 years but changing the DNA of mitochrondria would raise new ethical concerns. “This is not a simple form of gene therapy. This type involves replacing genes in the germline which will of course transmit it to the next generation and there are concerns,” Dr Mitalipov said. “We are talking of gene defects that cause terrible diseases. So the only way to prevent these genetic defects is to replace these genes whether we like it or not. We realise it’s gene therapy involving the germline,” he said. Professor Peter Braude, a specialist in reproductive medicine at King’s College London and director of the Centre for Preimplantation Genetic Diagnosis at Guy’s Hospital, said that the study involved a series of technically difficult experiments that were meticulously executed. “For the first time, proof of principle has been demonstrated that transmission of mitochondrial disease might be avoided. It is a first step toward preimplantation correction of the serious medical disorders caused by defective DNA inherited maternally in the mitochondria,” Professor Braude said. “The transfer of the normal genetic material from a mother who has defective mitochondria, to a clean donated oocyte (egg) with normal mitochondria would allow it to be fertilised with her partner’s sperm and for them to have a child free of the mitochondrial disease with the genetic material of the couple,” he said. A spokesman for the Human Fertilisation and Embryology Authority said: “If, in the future, safe and effective treatments are then developed to prevent the transmission of mitochondrial disease, Parliament would have to pass secondary legislation to allow that treatment to take place under HFEA licence. Any specific proposals would be closely examined by a Licence Committee to ensure that appropriate safeguards were in place.” —By arrangement with
The Independent |
|
Trends LOS ANGELES: Bouts of extreme muggy heat lasting for days, once rare in California, are becoming more frequent and intense due to ocean patterns altered by climate change, scientists said in a study released on Tuesday. Research meteorologists at the University of California’s Scripps Institution of Oceanography reached the conclusion after examining a severe 2006 summer heat wave that was blamed for the deaths of 600 people and 25,000 cattle in California.
Experts identify fungus-resistant gene in rice HONG KONG: Researchers in Japan have identified a gene that allows rice plants to fight off a fungal disease called blast, which may open the way for farmers to cultivate hardier plants. Using genetic sequencing, they were also able to separate the
gene, Pi21, from a nearby gene that is associated with a “poor flavour,” they wrote in a paper
published in Science. — Reuters
|
|
THIS UNIVERSE Is there any chance that the force of gravity on earth will stop attracting things?
You seem to have curious dreams. What you are saying is whether the world and the universe could suddenly disappear. If the force of gravity stops attracting on earth, the earth will also not be attracted towards the sun and will go on without bending in an elliptical path and escape the solar system. If the mass of the sun does not produce a container through its gravity the sun would explode into a large fireball that would eventually cool. Plants on earth will not know in which direction to grow and there will not be any trees. Ultimately the galaxies would disperse and the universe will come to an end. All these are silly consequences. Perhaps you were thinking of an exception for the earth, without affecting the gravity of rest of the universe. You are doing a parochial violence to the laws of the universe. That is a completely out of question. Why is the sky blue? You must have found that white light can be split up into colours when passed through a prism. Not only the prism that school children have in their laboratory, but also many other materials, including dewdrops and cut diamonds. We also see these colours in rainbows. Physically colour is a rough indicator of the wavelength of light. Red light has about twice the wavelength of deep blue. It is experimentally found and theoretically established in scattering with air molecules the blue part of the sunlight scatters about eight times more than the red light. When we turn our face to the sky what we see is this scattered light, which is dominated by blue. Indeed what we call the sky is nothing but this blue scatter. If there were no scattered light the sky would be black — as it is in space. I might mention two other things you must have noticed. Around sunset the sun looks orange coloured. At that time the light of the sun has to travel through a long path through the atmosphere. There is a lot of scattering in the air and the component of light scattered out is mostly short wave lengths, namely the blue colour. Robbed of the blue, and some green, the remaining light is only orange or red. Readers wanting to ask Prof Yash Pal a question can e-mail him at palyash.pal@gmail.com |
Such a procedure would break new ground and raise fresh ethical concerns over the direction of IVF research because it would lead to permanent changes to the genetic makeup of children that would be passed on to subsequent generations of the same families.
A nurse from the Swine flu Vaccination Alpha Team (SVAT) injects a test H1N1 vaccine at the University Hospital of Antwerp. Belgian research centres have joined the race to find a successful H1N1 vaccine and are testing the latest batch from a Swiss pharmaceutical company before the autumn when the number of cases of Mexican flu is expected to rise. — Reuters