SCIENCE TRIBUNE Thursday, September 12, 2002, Chandigarh, India
 

Scientific institutions fail to market their products
Biswajeet Banerjee
When the dropsy crisis plagued the country with over 60 deaths reported from the areas in and around Delhi, the Industrial Toxicology Research Centre (ITRC), based in Lucknow, came up with a device to detect adulteration in the mustard oil. The colour-detection strip, called CD strip, was set nominally at just 50 paise. 

If IVF laws don’t come soon, ‘chaos will’
Y. Bala Murali Krishna
E
minent gynaecologist G.A. Ramaraju has urged the Centre to formulate laws and ethical guidelines governing in-vitro fertilisation (IVF) and stem-cell technology "before the developments take an ugly turn in the country.’’

NEW PRODUCTS & DISCOVERIES
Helping-hand robot
T
he Shadow Robot Company, based in London, has received STG75,000 from the UK government to build a robotic arm to help people with physical impairments. Shadow’s goal is to produce a multi-functional robot that can be guided, trained and programmed to carry out useful tasks for people with disabilities.

Stem cells may help cure blindness
S
tem cells taken from bone marrow can grow new blood vessels in the eyes of mice, a development researchers say raises the possibility of treating some diseases that often lead to blindness in humans.

   SCIENCE & TECHNOLOGY CROSSWORD
 
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Scientific institutions fail to market their products
Biswajeet Banerjee

When the dropsy crisis plagued the country with over 60 deaths reported from the areas in and around Delhi, the Industrial Toxicology Research Centre (ITRC), based in Lucknow, came up with a device to detect adulteration in the mustard oil. The colour-detection strip, called CD strip, was set nominally at just 50 paise. The technology was even sold to an industrial unit, Nilofe, a unit of Basco, a Lucknow-based company.

But, the much-hyped CD strip failed to hit the market. As owner of Basco was not available for comments, one of the employees of the company seeking anonymity admitted that the company had not started production. "We had carried out a market survey and found people were not interested in this product, so, we have not started production," he said.

This and several other similar cases have put scientific institutions in a piquant situation: how to find market for their research products. Despite a full-throttled effort by the scientific institutions, the so-called people oriented researches of these organisations have failed to stir a feather in the market.

Even the prestigious Memory Plus capsule, formulations of which was developed by the CDRI by extracting bacosides from Brahmi and marketed by a Chennai-based company, Nivaran Herbal Private Limited, vanished from the Indian market as its users claimed that the drug failed to enhance memory as was claimed by advertisements. The drug was launched on February 28, 1996, by the then Prime Minister, P.V. Narasimha Rao, and even chess wizard Vishwanathan Anand was roped in to carry out advertisements. Once complains started pouring in, the CDRI, in a kneejerk reaction, cancelled the MoU signed with the company and entered into an agreement with another company, which is yet to start production.

Scientists in the CDRI blame the previous company for the debacle. Zaka Imam, Head Liaison Department of the CDRI said that the earlier company (Nivaran) had violated the MoU and was not using the bacosides — the basic extract of Brahmi — as per the prescribed limit. "Thus, we were forced to cancel the agreement," he added.

It could be a point of debate as who was at fault, but the fact remains that almost all the "people oriented" researches have failed to stir people’s imagination. In some cases, the scientific institutions have found buyers to transfer the technology, but in other cases the institutions are still waiting for prospective buyers for their products.

The failure of the institutions to make a mark in this fast paced advertisement-oriented market has disappointed scientists. "Crores of rupees and hours of perseverance are spent in one research. And we try to sell this so that the people could enjoy the fruits of the hard work of our scientists. But when we fail to create a niche for ourselves in the market, then it hurts us," said JK Johri, Head, Information Liaison department of the National Botanical Research Institute (NBRI).

The scientists vouch that there are a number of research projects which could have changed the lives of people - not only in cities, but also in villages. The ITRC’s Amrit Kumbh, a water purification device, is cheap and costs just Rs 250. According to Dr K.K. Gupta, Deputy Director, ITRC, this device was invented keeping in mind villagers. Technology is simple and the same was transferred to two companies, one Lucknow based company Shipra Scientifics and a Delhi company, Mathbin Scientific Agency. Under this technology, disinfection of water is based on physio-chemical principles. The life of the filter is three years or 10,000 litres of water.

Interestingly, both companies have still to start production. Mr Arvind, business partner in Shipra Scientifics, was candid enough to admit that they had yet to understand the nitty-gritty of this research. Dripping of filtered water starts after a point and the ITRC has not been able to plug this fault. "Yeh yantra hamare samazh hi nahi aaya (I cannot understand this contraption)," he said in a matter-of-fact tone

Faced with this eventuality, the ITRC, in fact, itself took up cudgels to ensure its advertisement. During Kumbh Mela and even in rural congregations, the device was put on display and people were apprised of the importance of clean water. Even during floods, the scientists carried this contraption to the inundated villages to drive home the point. "Despite all our efforts, the utility of this Amrit Kumbh has failed to impress villagers," said Dr Gupta.

Then, there are a few herbal researches of the NBRI. This year, the institute has sold its technology of herbal gulal to a Jharkhand-based company, DM Herbals, subsidiary of DM Shellac Pvt Ltd. Johri of the NBRI refused to divulge the rate at which the technology was transferred. But to his own admission, "herbal gulal was sold at a cheaper rate" because it concerned common people. As per the MoU signed between the NBRI and the DM Herbals the company will pay one time technology cost plus 3 per cent royalty on the ex-factory production cost.

In Lucknow, people are aware about herbal gulal, but did not know from where to get it. "We only knew that NBRI’s herbal gulal is up for sale, but where, no one knew. The whole thing was not even advertised properly," said Mahendra Pratap Singh, a real estate agent. Those who knew about it developed cold feet owing to its high price. "The price of herbal gulal was exorbitantly high," said Abhinav Sharma, a class 10 student of New Horizon Public School, Indira Nagar. He was not off the mark. The said gulal was sold at Rs 200 per kg against readily available gulal which was priced anything between Rs 50 and Rs 80 per kg.

High price might have turned the applecart of herbal gulal, but there are a few low-cost researches of the NBRI which had failed to find suitable buyer. The institute developed non-alcoholic herbal beer and lipstick. Against the normally available beer which is made from the fermented barley water and blended with hop’s extract, the NBRI’s beer is made from herbs. According to the NBRI scientists, it would be a health protective and "promotive" drink. The manufacturing cost, according to Johri, would be around Rs 6 per litre and could be sold in the market at Rs 20 per bottle. The institute is still looking for a prospective buyer.

Problem, according to scientists, is that the institutes have no mandate to market their research. "We have no expertise in this field," said Gupta of ITRC. Our mandate is to produce, not sell, he said and added: "Moreover, transfer of technology had not been a money spinning exercise for the institutions. We earn a little bit, but this earning is just peanuts."

The industry, however, is yet to hear about any such "people-oriented" research carried by the scientific institutions. The deputy director of the PHD Chamber of Commerce and Industry (PHDCCI) PK Srivastava showed his ignorance about any attempt made by the scientific institutes to sell their research. "We have over 250 industrial houses as our members. None of them has ever informed us about inclination to purchase a product developed by a scientific institute," he said.

The reason, according to Mr Srivastava, is that the scientific institutes do not interact with the industrial houses. There is no interface between the industry and scientific institutions per se. "No industry has even come to us asking us to arrange for finance to set up any special unit," said Srivastava.

However, this gloomy scenario has a silver lining too. There are a few drugs developed by the CDRI which had done a yeoman’s service to the mankind. The non-steroidal contraceptive pill Saheli and Arteether —a second generation anti-malarial drug — had been a success. "We have been able to produce import substitute drugs, thus putting less pressure on the pockets of people," said Zaka Imam.

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If IVF laws don’t come soon, ‘chaos will’
Y. Bala Murali Krishna

Eminent gynaecologist G.A. Ramaraju has urged the Centre to formulate laws and ethical guidelines governing in-vitro fertilisation (IVF) and stem-cell technology "before the developments take an ugly turn in the country.’’

Director of Krishna IVF Clinic, Dr Ramaraju, who has contributed a lot to human reproduction technology, said the government should wake up before the situation went out of hand.

"This is more so in respect of legal complications associated with surrogacy, donor insemination and stem-cell transfer technology as India too is keeping pace with the rapid developments abroad,’’ he said.

The government has started collecting information for the past four years on the subject, but failed to frame the guidelines and legislation governing the issues, the expert said.

As more state-of-the-art IVF clinics, with sophisticated technologies, are emerging in India and institutions with two cell lines are coming forward in the frontiers of research, the government "should take immediate steps before the research went wrong," he said.

Among the vexed issues that needed immediate definition and codification included the legal rights of a woman after the demise of her husband whose sperm was stored in sperm banks, the complications involved in handling surrogate mothers and the fate of frozen embryos of widowed mothers, Dr Ramaraju said.

The success rate in Indian IVF clinics was 30 to 35 per cent, as against a normal pregnancy rate of 15 to 20 per cent a month in the country, where childlessness due to various reasons was about 12 per cent among the women.

The cost of each operation, involving artificial fertilisation of the egg using the spermatozoa of the husband or donor sperm taking advantage of the laser technology, ranged between Rs 60,000 and Rs 90,000. UNI

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NEW PRODUCTS & DISCOVERIES
Helping-hand robot

The Shadow Robot Company, based in London, has received STG75,000 from the UK government to build a robotic arm to help people with physical impairments. Shadow’s goal is to produce a multi-functional robot that can be guided, trained and programmed to carry out useful tasks for people with disabilities. These functions could include fetching tissues, books or other items, picking up a telephone or collecting food from the kitchen. The technology the company has used to build its "helping hand" is called muscles," giving the robotic arm some functionality similar to human hands.

"In the future, we hope that the people will be able to ask the robot to do things like getting a glass of water," said Hugo Elias, one of the engineers helping to build the robot. "This would mean that the robot could go into the kitchen, find a glass, turn on the faucet, fill the glass and bring it to the person," he said.

Elias admits that such a complicated task is still as far as five or 10 years away, but the company hopes to have a working prototype that can perform simpler tasks in the next 18 months. This first prototype would be controlled through a wireless handset, similar to the interface used to drive remote controlled cars. Later models could have a voice interface, cameras, and artificial intelligence to let the arm cook, clean and perform other basic domestic tasks.

"When we ask people if they’d be interested in something like this, they say ‘Yes.’" Elias claimed. "They don’t say ‘I don’t know’ or ‘Maybe’ they say ‘Yes, we are very interested’. A lot of people have to rely on others to help them with these kinds of tasks."

The company has already constructed the arm portion of the robot and all that remains is to build the base that would allow it to move and the software that would run the machine. The company estimates that early models would retail for around STG10,000, Elias said. "Certainly people spend that much on a car, so we think they would pay that much for one of these," he added.

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Stem cells may help cure blindness

Stem cells taken from bone marrow can grow new blood vessels in the eyes of mice, a development researchers say raises the possibility of treating some diseases that often lead to blindness in humans.

In tests in mice, the stem cells injected into the eye became incorporated into the eye’s structure and formed new blood vessels.

If the process turns out to work in humans, the scientists hope to use it to treat eye diseases affecting the blood vessels in the retina. They include diabetic retinopathy and age-related macular degeneration, two leading causes of blindness.

Dr Martin Friedlander, who headed the research team at the Scripps Research Institute in La Jolla, California, said it may be possible to use the process to rescue sick blood vessels or, in modified form, inhibit the growth of abnormal vessels in the eye.

His research will be published in the September issue of the journal Nature Medicine.

Peter A Dudley, director of the retinal diseases program the National Eye Institute, said it is "extremely interesting" that the team was able to take certain precursor stem cells that can form blood vessels and then target them.

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SCIENCE & TECHNOLOGY CROSSWORD


Clues

Across:

1. The curve along which a projectile moves.

8. A sea animal with eight suckered arms and round mouth.

9. Abbr. for an Indian Institute of Technology.

10. Atmospheric vapour condensing in small drops on cool surfaces.

11. Either time when the Sun is farthest from equator.

13. A mechanism to do a work.

15. A diagram showing different strata met during a bore-hole in earth.

17. Flat and rigid sheet of metal with uniform thickness.

18. Abbr. for semi-automatic self loading rifle.

19. Designation of officer regulating use of armorial bearings.

21. Viscous inflammable substance.

22. Dome shaped snow hut used by Eskimos.

24. Association of 13 major oil exporting countries working together to have maximum income from oil.

25. A structure erected as support to electric power cables.

26. Yellow inner part of an egg.

Down :

1. Glands on each side of root of tongue.

2. Time measured by atomic clock.(abbr.)

3. A steel beam placed from wall to wall.

4. Words that are inscribed on a tomb.

5. Outer skin at the base of finger nail or toe nail.

6. A bitter leaved evergreen shrub.

7. Dark leaved evergreen coniferous tree.

10. Triangular alluvial tract at a river’s mouth.

12. Science related to diseases of ear.

14. A slippery and evasive snakelike fish.

16. Name for grid-iron put on windows for safety.

20. Artificial, enclosed body of water for parking of ships.

22. Abbr. for minimum potential through which an electron falls to ionise an atom.

23. A Latin term used by doctors and meaning ‘every night’.

Solution to last week’s Crossword:

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