118 years of trust


Wednesday, July 15, 1998

  All pains, no gains
NARAYAN’S wife had a tough delivery. No one in the village knows the name her parent’s gave her, so until she has a child she is known as the wife of Narayan...
Use anti-ulcer drugs cautiously
ANTI-ULCER drugs are one of the most commonly misused drugs in clinical practice. These drugs are also called anti-acid secreting drugs...
Cataract: from transparent to opaque
CATARACT remains one of the leading causes of visual disability and blindness all over the world. There are about 12 million blind people due to cataract in India alone...
The other side of Viagra
VIAGRA (sildenafil) has crossed the international boundaries, much faster than any drug in recent times...
Medical notes
  All pains, no gains
By Lindsay Barnes
NARAYAN’S wife had a tough delivery. No one in the village knows the name her parent’s gave her, so until she has a child she is known as the wife of Narayan. Her husband isn’t poor, by village standards. He has a job in the coal mines, earns around Rs 3000 per month. His first wife had two daughters in three years, got beaten up severely and regularly, and finally cracked up and left him cursing, “Narayan, you are no man! You will only ever produce daughters.” She left her daughters with him.Naryan’s second wife was in her ninth month when her mother-in-law died.
Forced to follow all restrictions following such a death, on top of all the normal restrictions that are imposed upon women during pregnancy, she acquired sores all around her mouth due to vitamin deficiency, on top of the chronic anaemia she already had. I was dreading her delivery.At midnight one day Narayan and his brother came to call me. When I saw her pathetic condition, and felt that the foetus seemed crooked, I tried to persuade her husband to take her to a hospital. “Where to get transport at this time of night?” he pleaded, “I’ll try in the morning.” I was half hoping she’d delay long enough, but she didn’t.
At dawn the baby was born, another daughter for Narayan. The mother couldn’t care less, she’d been falling asleep in between contractions throughout the night. She even fell asleep with the bady’s head hanging out and the body still inside. She began to bleed excessively, and the placenta got stuck. I gave her an injection of methergine to stop the bleeding, which I shouldn’t have done until the placenta was out. But the choice was a retained placenta versus haemorrhage.Then we called the village ‘dai’ to manually remove the placenta from the uterus, which she did expertly with her unwashed, ungloved hands. The choice this time was between a nursing home where the doctor would have done much the same with unsterile equipment, with less patience and sympathy, with bigger hands and perhaps a bigger risk of rupturing the uterus, for much, much more money.
The doctors always give antibiotics for all deliveries anyway, to pre-empt the inevitable infections. I, too, told Narayan to bring antibiotics for his wife.Anita’s delivery had much more ‘expert’ help. She was another delivery I was dreading, her legs, face and fingers were swollen, her blood pressure much too high - a condition known as pre-eclampsia. The doctor she’d been taken to see had advised her complete bed rest for one week, and then to return for her delivery in the hospital. Instead, her husband brought her back to her father’s house, much, much further away from the hospital, so her father, a colliery worker, could pay the bills. I told him not to call me for the delivery.
Five days later Anita’s husband and cousin came at seven in the evening. The labour pains had started. When I saw her pressure was dangerously high I told them to arrange a vehicle quickly. Two hours later a jeep arrived, and by midnight we reached the big hospital 25 kolometres away, in Bokaro Steel City.
Luckily Anita’s family had borrowed Rs. 1,500 to pay the admission fee, still it took me two hours to complete all formalities for getting her admitted. The driver was impressed, “If you hadn’t come it would have taken much longer, if they admitted at all.” Anita was pushed into a small room and her clothes and jewellery pulled off roughly by auxiliary staff who never ceased to curse her. Anita’s aunt, mother and I watched with apprehension as she was pushed into the labour ward — we were not allowed.
It took me another two hours to find a doctor who would tell me her assessment of Anita’s condition, then I led a weeping mother back to the jeep to go back home. Anita’s aunt and husband stayed behind, continually being pushed away from the corridor that led to the ward where Anita was lodged by staff who complained bitterly about ignorant, dirty villagers who clutter up the place. One hour later Anita was found wandering around confused and upset, hoping to find her way home, in the cold corridors outside. Her aunt, more vigilant than the staff, led her back to her fate.
After giving birth to a low-weight baby, Anita wasn’t allowed to breast-feed. One day later then began to allow her to feed her baby every four hours, during the day only. In-between, presumably, they were feeding the bady powdered milk. Three days later Anita was in tears, her breasts engorged and still separated from her baby. Six days later, under increasing pressure from Anita, mother, aunt, husband and all, against the doctor’s advice, I got them all released. None of them had bathed or eaten properly for six days, and all had big smiles of relief as we stepped out of the door of the hospital.
Then there is Bhagirat’s wife who was given four injections of dangerous hormonal drugs after 10 hours of labour by a local quack, even though she knows they can cause the uterus to rupture or even death. For this was her choice.
Whenever I am called to attend a delivery in these, not-really-so-remote village of south Bihar, it’s because there is no ‘choice’. I am not a doctor, not even a midwife, I don’t even encourage villagers to call me in the middle of the night to attend deliveries — but the fact that they still do is a sad reminder of their options. After attending my first delivery three years ago I asked the elderly village women what they did when things went wrong.
I asked them about village dais. Weren’t there any skilled old women who could manage difficult births? They shook their heads, the ‘dai’ only comes after the baby has been born. What about private doctors, qualified or otherwise? They only come to give injections, they don’t wait around to attend the delivery, they said. Then what about the government hospital? There’s eight bedded Primary Health Centre with doctors, midwives and other staff only seven kilometres away. The women just looked at me blankly, no-one knew of its existence. Or the big hospital in Bokaro Steel City, 25 km away? That’s only for employees, they told me, unless you’ve got Rs 1,500 ready at hand. Well, then, private nursing homes? But how can we get there in the night, and then to pay the huge bills we’ll have to sell our land. So, I asked finally, what do you do then? They answered with their silence — Unnati Features.
(The writer is a voluntary health worker.)
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  Use anti-ulcer drugs cautiously
By Atima Gupta
ANTI-ULCER drugs are one of the most commonly misused drugs in clinical practice. These drugs are also called anti-acid secreting drugs since they reduce/stop secretions of hydrochloric acid in the stomach. Acid production is normally there in all human beings. Presence of an optimal levels of acid is very essential for our digestion and it protects us from common food-brone infections like typhoid, protozoal and also against tuberculosis. Acid kills many disease causing bacteria and other organisms which are present in our food and can infect us.
Our diet containing spices and masalas leads to higher acid secretion. Stresses and strains also increase the acid output. Regular intake of tea, coffee, cold drinks and fried food further adds to the woes of such cases. Some patients suffer from chronic acidity going for months and years together. Medical research in the past one decade has clearly established the role of H.pyloric infection in causing peptic ulcer. Patients of peptic ulcer have symptoms of increased acid secretion and pain in the abdomen. In the case of gastric ulcers pain becomes worse following intake of food. Acute stress is well known to precipitate acid peptic disease.
The acidity component of acid peptic disease can be easily managed by commonly used antacids which directly neutralise the acid in the stomach. Regarding the role of anti-ulcer or anti-secretory drugs medical literature is very specific. Common anti-ulcer drugs are ranitidine, cimetidine, omeprazole and lansprazole. These drugs are marketed with trade names of Zinetac, Ocid, Topcid, Lan etc. Experts recommend use of these drugs in proven cases of peptic ulcer and severe reflux oesophagitis, where the stomach secretions regulate into food pipe. They are to be given in acute cases only for a period of six to eight weeks. It is generally agreed that these drugs are not to be given for maintenance therapy unless specifically indicated.
If taken for prolonged periods extending for few months to few years, these drugs can lead to a pathological condition of absence of acid in the stomach, called as ‘achlorhydria’. Because of achlorhydria there is poor absorption of vitamins. This loss of acid also makes intestinal tract more vulnerable for a number of infections. Even cases of fungal infections of the gastrointestinal tract have also been reported following prolonged use of these drugs. Many patients with chronic acidity or pain abdomen take anti-ulcer drugs for months together without any medical advice.
Such a practice should be highly discouraged. It is very commonly observed that many persons take anti-ulcer drugs following intake of alcohol or heavy meals. It is a not a scientific practice. Common side-effects of these anti-ulcer drugs are headache, cough, constipation and impotence. It has been well documented that long term use of omeprazole can cause tumors in the stomach of mice.
For treatment of acid-peptic disease alone anti-acids and anti-ulcers drugs are not enough. Such cases have to be added antibiotics like clarithromycin, amoxycillin and drugs like tinidazole and bismuth salts.
Today the dictum is, no H-pylori (bacteria)-no ulcer. So unless cover of antibiotic is given along with, patient of acid peptic disease is not going to be cured. But in general medical practice family physicians have yet to pick up the habit of prescribing antibiotics for this problem.
Common drugs used in clinical practice which can make the patients of acid peptic disease worse are pain killers, oral contraceptives, steroids and antibiotics. Irregular sleeping habits can also lead to the problem. Since chronic acidity is quite a common problem it is being frequently observed that many patients indulge in completely irrational and unscientific use of anti-ulcer drugs.
Simple antacids are ideal choice for problem of chronic acidity. Patients should also remember that unless they improve their dietary habits and reduce their life tensions, regular intake of acid reducing drugs and antacids are not going to solve their problem.
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  Cataract: from transparent to opaque
By Parveen Parkash
CATARACT remains one of the leading causes of visual disability and blindness all over the world. It is estimated that there are about 12 million blind people due to cataract in India alone. Cataract results from the clouding of the eye’s natural lens and can be formed at any time in the life of an individual from embryonic to old age, therefore cataract is either congenital or senile which is a normal part of the aging process. Congenital or embryonic cataract is present at birth or is seen within three months of the birth. It is either genetic or due to maternal malnutrition. Certain metabolic diseases of mother or her exposure to X-rays during first trimester can also cause congenital cataract.
Due to increasing life span more and more people are suffering from senile cataract these days. Senile cataract seems to occur at a much younger age in the Third World as compared to the patients in rich countries. Other causes of cataract include certain diseases, drugs, chemicals, trace metals, smoking and radiations.
Causative factors
In addition to congenital and senile cataract various other causative factors of cataract formation have been identified and these include:
  • Exposure to X-rays Gamma or ultraviolet rays.
  • Use of certain drugs e.g. dinitrophenol, naphthalene, lactose, thallium and chlorpromazine.
  • Certain diseases of the eye e.g. iridocyclitis, retinitis pigmentosa, chorioretinitis and total retinal detachment.
  • Certain systemic diseases e.g. diabetes mellitus, cretinism and myotonia atrophica.
  • Passage of strong electrical current through the body.l
  • Deficiency of amino acids e.g. tryptophan and cystine and vitamins e.g. vitamin C and B-complex.
  • Certain occupations e.g glass blower and iron melter.

Symptoms of cataract are entirely visual. Patients often say, ‘newsprint is very indistinct these days’, they have to push chair closer to TV set, glare make it hard to drive at night or the house needs painting. Various pharmacological strategies have been proposed for prevention and treatment of senile cataract. But till day no anti-cataract drug is approved for medical therapy of cataract in the world. The only remedy at present is extirpation of the cataractous lens through surgery.
The lens is transparent, biconvex structure suspended immediately behind the iris, retained in position by a delicate group of radial fibres originating from the ciliary body and inserting into the lens capsule. The lens is made of innumerable fibres arranged in concentric layers like scales of onion. Individual fibre can be identified more readily in the outer part known as cortex than in the inner part, called the nucleus of the lens, where the fibres are condensed and appear more homogenous. The anterior surface of the lens is covered by a layer of cuboidal epithelial cells.
The lens is free of blood vessels and neural elements and rely for its nutrition on oxygen and other nutrients supplied by the aqueous humour. It is surrounded by capsule, which is a transparent elastic membrane enclosing epithelial and fibre cells of the lens. The lens capsule is constantly under tension and hence is capable of changing the shape of lens. It also acts as a permeable barrier between the aqueous humour and lens fibres.
A clear lens focuses light sharply on transparent retina forming distinct image of object. The crystalline lens grows throughout life, becoming thicker by about 20 microns every year. It has been estimated that the amount of light that reaches the light-sensitive photoreceptors of the retina decreases linearly from age 20 to 65 years due to decreased transparency, yellowing and opacification of the lens. Cataractous lens increases light scattering and thus reduces the vision and objects appear hazy, blurry or dull. Senile cataract occurs equally in men and women and is frequently bilateral although one eye may be affected earlier than the other.
Transparency of the lens depends on the physico-chemical state of the lens proteins. Loss of transparency during human cataract formation results from a variety of complex metabolic and physiological mechanisms which act in combination to change refractive index of the lens thereby making it opaque.
Numerous studies of lens proteins indicate that post-translational modifications occur in lens proteins during cataract formation and are the result of various chemical actions which include oxidation, glycation, Schiff base formation, proteolysis, transamidation, carbamylation and phosphorylation.
The post-translational modifications alter attractive forces between lens proteins to favour aggregation, disruption of normal lens structure and opacification. Glutathione, a tripeptide thiol, has been reported to control calcium influx and protect the lens proteins against damaging effects of sugars. With advancing age the concentration of glutathione decreases and hence the lens loses its protective power against sugars.
As the lens ages, it loses water and becomes denser and less elastic. Consequently, its range of focus becomes diminished and individual requires supplementary lenses for focusing near objects. Excessive free radical attack also hasten the process of cataract formation.
Though many factors have been identified yet complete understanding of cataract formation still eludes scientists. Attempts are being made to induce cataract in experimental animals by making them diabetic. Cataractous lens of these animals contain excessive amount of sorbitol which is synthesised from glucose by the action of an enzyme aldolase reductase. Researchers are also looking for anti-cataract agents and have identified many of them. They include non-steroidal anti-inflammatory drugs e.g. aspirin, paracetamol and ibuprofen; aldolase reductase inhibitors e.g. alrestatin, sorbinil and sulindac; micronutrients e.g. zinc, copper and manganses; and antioxidants e.g. riboflavin, vitamin C, E and B-carotene. It is probable that some agents will come up soon and will be useful in delaying the onset and progression of cataract formation in humans.
Treatment: It involves surgical removal of the affected lens. During operation an incision is made round the periphery of the cornea and the cataractous lens is gently drawn out through dilated pupil. Extraction of the lens is either extra-capsular or intra-capsular. In extra-capsular extraction the nucleus and most of the cortex of the lens is removed leaving behind the capsule with small amount of cortical matter. In intra-capsular extraction, the entire lens including, its capsule is removed.
These days a special technique called phacoemulsification is employed. This involves breaking apart of old lens with ultrasound and then removing its pieces. This procedure requires a small incision and hence healing and recovery of patient is faster. Once the old lens has been removed, surgeon slips the new lens called intraocular lens (IOL) through the small incision. After the new lens has been positioned, surgeon close the incision. Some incision are closed with stitches, while others are selfsealing. That means they will stay closed on their own without stitches.
The IOL does much the same as your old lens did before it became cloudy. It focuses light letting you see sharp images and vivid colours. These lenses are made of PMMA i.e. poly metho metha acrylate and normally last a lifetime
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  The other side of Viagra
By S.K. Kulkarni
VIAGRA (sildenafil) has crossed the international boundaries, much faster than any drug in recent times. A record breaking 1.7 million prescriptions have been written in the USA alone since it hit the market in April 1998. In many countries, including India, it is available at phenomenal cost. Newspaper editorials and magazine columns have started discussing the drug. Even the topics for discussion in kitty parties has been around Viagra, said one report, where wives of middle-age to octogenarian husbands shared the new-found vitalities of their hubbies.
Viagra (Pfizer trade name for sildenafil), is a phosphodiestrase V inhibitor used for the inability to obtain and sustain erection. This is a common problem in men and the prevalence increasing with age. This can be due to organic, psychological or often complicated by both the causes. It has to be distinguished from ejaculatory disorders including premature ejaculation and ejaculatory failure. Impotence could be a symptom of underlying diseases such as heart disease and diabetes. Many drugs including antihypertensives, cimetidine, antidepressants are reported to produce dysfunction.
Viagra (25-100 mg/day orally) is reported to be well tolerated and highly effective in dysfunction due to organic, psychogenic or mixed causes. Patients and partners rated the effect as superior to placebo. The degree of satisfaction is reported to be higher in patients with Viagra as compared to placebo-treated group.
However, side-effects are reported to be mild included headache, vasodilation, facial flushing, dyspepsia (indigestion) and diarrhoea. In a recent report the Food and Drug Administration (FDA) in the USA has warned about the deaths due to Viagra and maintained the possibility of dangerous drug interactions with other drugs as older patents (80 years) may be taking drugs for treatments of other ailments as well.
More recently it has been observed that Viagra being mixed with other party stimulants and this could be a deadly cocktail. Three men reportedly died after Viagra as they were addicted to amphetamines. Whether hitting the bed early with Viagra is more revitalising or accepting the age related changed in sex life as a consequence of nature is matter of individual attitude. We are, anyway, in for a cultural change.
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Medical notes
Aspirin’s long-term benefits
AN emergency treatment with normal aspirin and a “clot busting” drug for a heart attack victim could save the patient’s life for another 10 years, according to ANI.
Benefits of this emergency treatment were discovered by an international study of more than 17,000 heart patients in 16 countries, reported the British Medical Journal.
Earlier studies had not indicated the long-term benefits of the treatment, though doctors were aware that anti-clotting drugs like streptokinase and aspirin improved a patient’s chances of improvement. “We now know that the benefits of these emergency treatments last for at least 10 years, even in older patients,” Dr Colin Baigent, a member of the research team, said in a statement.
“This study shows that the early treatment of heart attacks with aspirin and clot-buster produces substantial long-term survival benefits. This is an important finding which should help ensure that as many patients as possible have the opportunity of benefiting from this treatment,” said Prof Brian Pentecost, medical director, British Heart Foundation.
In most cases heart attacks occur because blood clots block the coronary arteries that supply blood to the heart muscle. Taking half an aspirin for a month after an attack had lasting benefits, showed a follow-up study of the second international study of infarct survival.“Unless these drugs are unsuitable for a particular patient, aspirin and a clot-buster should generally be given as soon as possible after patients with a heart attack reach hospital,” said the statement.
Japanese putting on weight
ONE in three office-going Japanese in their 30s is overweight due to a life of office work, late nights at bars and restaurant meals, according to ANI. According to a Health and Welfare Ministry survey, reported by the Yomiuri Shimbun paper, while men have been putting on weight because of a more sedentary lifestyle and more fatty foods in their diets, country’s women have been slimming down.
The survey was conducted on body mass index and found that 33.6 per cent men in their 30s were overweight. The figure for men in their 40s was 37.6 per cent and for men in their 50s it was 38.8 per cent. The survey said all age categories for men experienced a gain of between one and three percentage points in body fat from a similar survey conducted 10 years ago.
The survey surprisingly found that 44.1 per cent of women in their 20s were below the benchmark average bodyweight, a significant rise from the 31 per cent marked in a similar survey 20 years ago.
The paper said the same was true for women in their 30s, with 34.1 per cent falling into the thin category, a much higher figure than in previous surveys from 10 and 20 years ago.
Degrading environment a killer
INTERNATIONAL health experts commenting in a report jointly prepared by the World Bank, the United Nations and the World Resources Institute, have claimed that a rapidly degrading environment is killing one in five children before age five in the poorest areas of the world, according to ANI.
The experts said that vector-borne diseases, spread by insects and rodents, like malaria, diarrhoea, cholera, pesticide poisoning, and respiratory infections from air pollution were contributing to about 11 million childhood deaths a years.
The report identified the world’s poorest areas as much of sub-Sahara Africa and parts of Asia.
Mr Gus Speth, an administrator with the United Nations Development Programme, said information on the link between the environment and human health, although not dramatically new, suggested that the problem was both pervasiveness and shocking.
The report said that nearly four million children died each year from acute respiratory infections linked to indoor pollution from smoky cooking fires and other sources, and from outdoor air pollution. Another one to three million people, mostly children, succumbed to malaria, while 2.5 million children and 3.5 to five million people died from diarrheal disease or acute pesticide poisoning respectively.
The poor on the other hand would continue to suffer from effects of global warming, caused by the accumulation of gases in the atmosphere from burning fossil fuels.
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